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Methods of Cold Plasma Treatment of Brain Tumor

Technology #017-042-keidar

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In vivo bioluminescence imaging shows reduction of glioblastoma tumor volume with He CAP treatment compared to the vehicle control (treated with only helium).
Categories
Researchers
Michael Keidar
External Link (mpnl.seas.gwu.edu)
Jonathan Sherman
Colin N. Young
Zhitong Chen
Hayk Simonyan
Managed By
Brian Coblitz
Sr. Licensing Associate coblitz@gwu.edu (202) 994-4345
Patent Protection

US Patent Pending
Publications
A Novel Micro Cold Atmospheric Plasma Device for Glioblastoma Both In Vitro and In Vivo
Cancers,

GW researchers developed a novel micro-sized cold atmospheric plasma (CAP) device in order to target glioblastoma brain tumors in vivo. CAP is made when gas is ionized at room temperature. CAP induces apoptosis in cancer cells without harming normal cells. GW already commercialized a CAP device to be used in tumor surgeries to remove potential tumor cells left behind in the area around the removed tumor. The commercial device is much too large to be used in brain surgery.

Treatment of brain tumors requires particular care, because of the brain’s susceptibility to damage and limited reparability. Surgery remains a primary treatment of glioblastoma brain tumors, because many drugs cannot cross the blood brain barrier and the tumors are very resistant to conventional therapies. To apply CAP within the brain, GW researchers created a new micro-sized CAP (mCAP) device. The prototype mCAP device safely suppressed tumor growth in mice.

Applications

  • Cancer therapy

Advantages

  • Tiny device reaches tumors previously untreatable by CAP
  • Delivers CAP to tumors in situ