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Stem Cell Therapy for Obesity and Type 2 DiabetesTechnology #016-050-sen
Questions about this technology? Ask a Technology Manager
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- Sabyasachi Sen
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- Brian Coblitz Sr. Licensing Associate email@example.com (202) 994-4345
- Patent Protection
- Provisional Patent Application Filed
- Genetic modification of human mesenchymal stem cells helps to reduce adiposity and improve glucose tolerance in an obese diabetic mouse model Stem Cell Research and Therapy, 2015; 6: 242.
Patients with type 2 diabetes have high blood sugar levels due to inadequate insulin production. This could be coupled with insulin resistance and inflammation. High blood sugar levels over a long term can lead to blindness, kidney failure, heart disease and nerve disease which commonly lead to amputations. Overweight and obese people have a much higher risk of developing type 2 diabetes compared to those with a healthy body weight.
One component of the chronic impact from both diabetes and obesity is an increase in reactive oxygen species (ROS) leading to chronic oxidative stress. Usually, antioxidant enzymes called superoxide dismutase (SOD) work to decrease ROS inside a cell which may be lacking in a chronic high glucose state of diabetes and obesity.
Our treatment increases anti-oxidants inside the cell, where they are needed. Our therapy delivers genetically engineered fat-derived mesenchymal stem cells (MSCs) containing increased anti-oxidant enzyme, SOD2, to the inflamed fat depots. Intraperitoneally injected stem cells home in and integrate with the body's fat deposits. This suppresses fat cell -mediated inflammation and improves insulin resistance as evidenced by improved glucose tolerance. The treatment is validated in a diet-induced obesity diabetic mouse model. SOD2-treated mice had improved glucose tolerance and reduced body weight.
Diabetes and obesity therapeutics
Avoids the multiple co-morbidities of a bariatric surgery.
Directly targets insufficiency of antioxidants, intra-cellularly.
- Transforms white fat into brown fat
Improves glucose tolerance test
Reduces body weight