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Treatment of U87 Glioblastoma cells with Plasma Discharge Tube at different time durations (1, 2 & 3 Minutes)

Non-Invasive Plasma Discharge Tube Device for Treating Brain Tumors

019-062-keidar – Treating brain tumors, like glioblastoma, is challenging. Current glioblastoma drugs, Rapamycin and Temozolomide (TMZ), generally only extend life for a matter of months, are not very effective in treating recurring tumors, and have significant clinical toxicity. A novel Plasma Discharge Tube (PDT) device has the potential to be more effective and less toxic. PDT may be used alone or may be... Read More

HDACi potency and HDAC6 selectivity index (SI)

Highly Potent and Selective HDAC6 Inhibitor for Cancer Treatment

020-031-villagra – GW and UIC researchers developed a highly potent Histone Deacetylase (HDAC) inhibitor. HDACs can modulate a multitude of cellular processes and are a part of the regulation of cellular pathways involved in antitumor immune responses. Selective inhibition of HDAC6 slows tumor growth in various cancer models. Currently, many prominent selective HDAC6 inhibitors (HDAC6i) are limited to... Read More

In mice, M1+HDAC6i shows a significant decrease in melanoma tumor size compared to Vehicle or untreated M1.

HDAC6i-Activated Macrophage Cell Therapy

019-057-villagra – The tumor microenvironment (TME) plays a key role in tumor growth and survival. Often the immunosuppressive nature of the TME prevents success of treatments including immune checkpoint blockade (ICB), radiation therapy (RT), and chemotherapy. Macrophages in the TME contribute to its immunosuppressive or immunostimulatory character. M2 macrophages secrete anti-inflammatory cytokines, such as... Read More

Illustration of micro-wells transforming into micro-grooves over time at 37°C.

4D-Printed Programmable Culture Substrate for Controlling Neural Stem Cell Growth

020-006-zhang – Neural stem cells (NSCs) exhibit great promise for treating neurodegenerative diseases and injuries. Treatments will rely on efficient proliferation and differentiation of NSCs into neurons with therapeutic characteristics. Static 2D and 3D microenvironment culture substrates fail to cater to the dynamic cell needs, resulting in sub-optimal, inefficient and uncontrolled differentiation of... Read More

Cisplatin resistant ovarian cancer tumor growth is slowed when treated with DHS. The combination of DHS and Cisplatin proves even more effective, highlighting the re-sensitization of the cancer cells to Cisplatin.

And-1 Inhibition by DHS for Cancer Treatment

017-039-zhu – GW researchers developed DHS (4,4’-trans-dihydroxystilbene) as a new cytotoxic anticancer drug for use alone or in combination with other chemotherapies. Drug toxicity and drug resistance limit the ability of many cytotoxic cancer drugs to effectively treat cancer, a problem which is overcome by DHS. The cancer killing efficacy of DHS is 10-times better than its parent compound, resveratrol,... Read More

(Technology Bundle) Stem cells with transiently reduced p53 to treat diabetes associated kidney disease and peripheral vascular disease

018-044-sen-019-54-sen – Local delivery of endothelial progenitor cells (EPCs) may treat diabetic-related kidney disease (DKD) and peripheral vascular disease (PVD). EPCs may be obtained from a patient’s peripheral blood. The hyperglycemic state in diabetic patients causes transplanted EPCs to undergo apoptosis, creating a challenge for such therapies. By transiently silencing the apoptotic gene p53, Dr. Sen’s... Read More

PASSIVE RAM-AIR INERTIAL STABILISATION MECHANISM

020-001-waldron – Students at the George Washington University are developing a passive stabilization mechanism for atmospheric rocket flight which extracts work from oncoming air to generate a restoring force. Airflow channeled through a turbine section spins a shaft, which exerts a torque proportional to its speed and perpendicular to the rocket’s trajectory. This additional stability allows for a... Read More

CMOS Compatible Light Emitting Tunnel Junction for Photonic Integrated Circuits (PIC) and Optical Communication

019-055-sorger – With the emergence of photonic integration, the challenges (a) to create light from silicon and (b) to realize electronically compact photonics have delayed the anticipated introduction of photonics into electronic consumer products. While a variety of light emitters exist such as LEDs and semiconductor solid-sate-lasers, existing technology is hindered by: specialized and costly materials... Read More

golf ball on work bench and graphs shoing ball speed and distance

NEXT GENERATION OF GOLF BALL DESIGN

018-023-balaras – Researchers at the George Washington University and Arizona State University have been developing a family of novel golf ball designs that can reduce drag by as much as 15% compared to traditional designs based on dimples. The new designs will allow for improved aerodynamics performance which can be used to increase the distance the ball travels or to improve the feel of the ball. Dimples... Read More

PMU-Embedded Analytics for Online Event Detection and Classification in Power Grids

019-027-deghanian – Researchers at The George Washington University are developing innovative analytics for power grid online surveillance (event detection and classification with minimum latency) and real-time situational awareness. The novel analytics can be deployed as a stand-alone next-generation smart sensor or can be embedded within the existing phasor measurement units (PMUs) and intelligent... Read More

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