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: “Spark-cell” spheroids can be manufactured in a high-throughput (HT) format, and can be positioned onto hiPSC-cardiomyocytes, also grown in HT format. Shown is calcium response (trace and optical map) triggered by light engaging a deposited “spark-cell” spheroid.

3D Biophotonic Devices for All Optical Electrophysiology

021-036-entcheva – Optical actuation and sensing methods were demonstrated by GW for high-throughput drug and cardiotoxicity screening. However, modification of target cells takes time, has variable yield and can cause potential interference with cell’s innate functional responses. GW researchers manufactured “spark-cell” spheroids, used as a reagent that can be frozen, transported, and deployed on-site... Read More

An Approximate Communication Framework for Network-on-chips

020-058-louri-yuechen – Prof. Louri and his research team at the George Washington University have developed an approximate communication framework for network-on-chips (NoCs), which significantly reduces the latency and power consumption of on-chip data movement. The invented framework leverages the fact that big data applications (e.g., recognition, mining, and synthesis) can tolerate modest error and transfers... Read More

Learning-Based High-Performance, Energy-Efficient, and Secure Interconnection Design Framework

020-057-louri-ke – Researchers at the George Washington University have invented a novel network-on-chip framework, named TSA-NoC, which significantly improves on-chip security. The invented framework also minimizes the latency and cost of security techniques for simultaneously improving system-level performance and power. As the market for parallel computing is growing rapidly, the number and complexity of... Read More

Forseti: Dynamic Chunk-level Reshaping for Data Processing on Heterogeneous Clusters

020-061-subramanian – Researchers at the George Washington University have invented a novel algorithm for large-scale computing frameworks running on a distributed heterogeneous system to process large amounts of data. The algorithm minimizes job execution time by balancing residual workloads in heterogeneous environments and provide significant improvement in performance. The algorithm has the ability to reshape... Read More

FABRICATION OF SEMICONDUCTOR AND THERMOELECTRIC MATERIALS BY ADDITIVE MANUFACTURING

018-030-leblanc – Researchers at the George Washington University have invented a novel additive manufacturing technique for fabrication of semiconductor and thermoelectric structures of various shapes and sizes, as required for specific electronic and thermoelectric applications, via selective laser melting (also known as laser powder bed fusion and direct metal laser sintering). The additive... Read More

Polyhedra Golf Ball with Lower Drag Coefficient

018-023-balaras – Researchers at the George Washington University have invented a novel class of golf balls having a polyhedra design that can yield lower drag coefficient than designs based on dimpled spheres. The drag reduction is applicable to other sports equipment in general having a bluff body, such as the head of a golf club or a bike helmet. For the past 100 years the vast majority of commercial... Read More

Robotic Therapy for Children on the Autism Spectrum

016-056-park – Researchers at the George Washington University have invented a novel emotional interaction robot and a robotic therapy for children and particularly for children on autism spectrum. The robotic therapy uses behavioral analysis automation to provide treatment and assessment of emotional communication and social skills of children with autism. The rapid increase in the population of... Read More

Organ-on-Chip high-throughput apparatus for in vitro preclinical trials on human cardiac slices

017-025-efimov – Researchers at the George Washington University have invented a novel apparatus and method allowing high-throughput testing of pharmacological agents and therapeutic virus on human tissue (e.g. human cardiac slices). The apparatus can be used to create induced disease models for testing of therapies targeting specific diseases.  For example, heart failure can be induced in cardiac slices... Read More

FAST LABEL-FREE METHOD FOR MAPPING CARDIAC PHYSIOLOGY

019-018-efimov – Researchers at The George Washington University are developing a fast label-free mapping system of excitation-contraction-metabolic waves at hundreds to thousands (e.g., 100-5,000) of frames per second for mapping cardica physiology. Such a system allows for clinical mapping of atrial and ventricular arrhythmia during, or prior to, ablation procedures to guide such procedures through the... Read More

siSptbn1-treated mice accumulated less visceral body fat, had lower blood triglycerides (TG) concentrations than siCtrl-treated mice.

siRNA therapy to treat Obesity/ NASH and Obesity/ NASH-driven cancer

020-030-mishra – Obesity-associated nonalcoholic steatohepatitis (NASH) and liver cancer are increasing. Treatments are not currently available that reverse both the steatosis and fibrosis hallmarks of NASH. The leading causes of this disease are lipogenesis and fibrosis.  GW researchers found that a high-fat diet (HFD) induced an increased expression of SPTBN1 and CASPASE3. Thus, identifying new potential... Read More

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