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Enhanced expansion of activated CD4 T-cells in vitro over 30 days with addition of drug (red) compared to control (blue).

In vitro drug treatment to proliferate and activate effector cells for immunotherapy

018-063-bosque – STAT5 SUMOylation inhibition increases CD4 and CD8 T-cell proliferation and and production of immune effector molecules in CD8 T-cells and NK (natural killer) cells. Both attributes address critical limiting factors in applying cell therapies to fighting cancers and pathogens. The difficulty of obtaining enough activated effector cells limits the efficacy of cell therapies. In vitro drug... Read More

6 weeks after implantation. The images show maintenance of high cell viability and improvement of myocardial infarction.

Thick 3D Bioprinted Cardiac Patch with Anisotropic and Perfusable Vessels

018-012-zhang – GW researchers fabricated a vascularized patch of cardiac tissue suitable for cardiac regeneration using 3D bioprinting. Cardiovascular disease involving myocardial infarction is a major cause of morbidity and mortality worldwide. Following myocardial infarction, adult cardiac tissue cannot significantly repair or regenerate itself. Current therapies include autografts, allografts,... Read More

Distributions of metabolites kempferol/luteolin (red scale) and chlorophyll a (blue scale) in a zebra plant leaf at multiple depths.

Laser Ablation Electrospray Ionization (LAESI) Mass Spectrometry: matrix-free ambient 2D or 3D imaging of living tissue without sample preparation

006-000x-vertes – LAESI provides very precise in situ chemical analysis of biological samples using mass spectrometry (MS) technique. LAESI enables 2D and 3D imaging of metabolites, lipids, peptides and proteins in biological samples at the single cell level, empowering rapid chemical analyses in multiple fields of biology, medicine and chemistry. The LAESI device embodies an ionization source / sample... Read More

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Microencapsulation of Chemical Additives

015-014-hsu – There is a need for a new process for encapsulating complex chemical additives, where microcapsules can give strong performance under hostile chemical and mechanical conditions. While microencapsulation technique is a mature technology, microcapsule products made by traditional techniques may work well only in relatively simple, passive and non-hostile conditions. On the other hand, in... Read More

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Friction Reduction for Engine Components

011-0021-hsu – The demand for automobile energy efficiency and higher emission standards encourages the development of modern engines and drive trains that have lower frictional losses at various contact surfaces. One solution for reducing such frictional losses is to add texture modifications to engine/drive train surfaces that come in contact with one another during operation. However, previous... Read More

DOPED GRAPHITIC CARBON NITRIDES

015037-shuai – A growing number of persistent organic micro-pollutants such as pharmaceuticals and personal care products, pesticides, and herbicides are frequently observed in natural and treated water. Such contaminants are recalcitrant to conventional water and wastewater treatment and may pose risks to human and ecological systems even at very low concentrations. In addition, persistent... Read More

experimental setup

Compact Near-IR and Mid-IR Cavity Ring Down Spectroscopy Device

006-000x-miller-u – Compact Near-IR and Mid-IR Cavity Ring Down Spectroscopy Device There are many technologies available for measuring trace amount of gas species, but there are tradeoffs between accuracy, sensitivity, selectivity, size and cost. For example, while tunable diode laser absorption spectroscopy may provide easily-interpreted spectrums for many gas species, this method generally can be orders... Read More

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Catalytic Transfer Hydrogenation of CO2 to Potassium Formate using Glycerol as a Hydrogen Source

017-053-voutchkova – To simultaneously transform COand glycerol, two low-value by-products, into formate and lactate can be highly economically attractive. Presently, however, it is challenging to achieve the reaction on an industrial scale. GW researchers developed novel single-site supported heterogeneous catalysts that can simultaneously convert COand glycerol into formate and lactate under batch or... Read More

Increased dye penetration with treatment of ultrasound at higher frequencies

Ultrasound Enhanced Drug-Delivery for Treatment of Nail Fungus

017-015-zderic – Nail fungus causes nails to thicken, turn yellow or cloudy in appearance. This disease has proven to cause pain, discomfort and social embarrassment in patients. Systemic treatments for nail fungus have dangerous side-affects such as elevated liver function tests and hepatitis. Topical treatments for nail fungus take many months to work and only work for a small percentage of patients.... Read More

The amount of type II collagen per scaffold for weeks 1-3 in the control, the ultrasound treated scaffolds, and the ultrasound treated scaffold with microbubbles.

Microbubble and Ultrasound Therapies to Enhance Cartilage Repair and Regrowth

017-022-sarkar – By combining low intensity pulsed ultrasound (LIPUS) with lipid coated microbubbles, researchers at GW increased differentiation of human mesenchymal stem cells (hMSCs) into cartilage. Existing treatments for damaged cartilage include autografts, allografts, and total joint replacement. Autografts suffer from donor site morbidity and insufficient donor tissues, allografts have negative... Read More

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